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The anticipation is palpable as the NFL preseason concludes, shifting all eyes to the exhilarating Week 1 schedule, now just days away. This year’s opening slate promises high-octane action, kicking off with a blockbuster Cowboys vs. Eagles showdown in the 2025 NFL Kickoff Game on Thursday. The excitement continues Friday with Chiefs vs. Chargers battling it out in Brazil, followed by a packed Sunday featuring thirteen contests, and a Monday night finale between the Vikings and Bears.
For avid NFL bettors, Week 1 presents a prime opportunity to target spreads, totals, and money-line picks. Key Week 1 NFL odds include the Eagles at -7.5 against the Cowboys, a line that has shifted a half-point since the significant Micah Parsons trade. Meanwhile, the Vikings are favored at -1.5 against Chicago, and in a marquee Sunday Night Football clash between AFC contenders, the Bills stand at -1.5 against the Ravens.
To navigate this thrilling opening week, an accurate set of Week 1 NFL score predictions can prove invaluable. These insights not only guide your traditional bets but also offer a roadmap for various NFL prop bets, potentially leading to substantial payouts if you hit on an exact score. Before placing any Week 1 NFL picks, it’s imperative to consult the expert analysis from SportsLine’s Eric Cohen.
Meet the Expert: Eric Cohen’s Proven Track Record
SportsLine expert and host, Eric Cohen, has meticulously evaluated the entire Week 1 NFL slate, providing precise score predictions and the underlying logic for each matchup. Cohen concluded the 2024-25 season with an astounding 190-95 record on straight-up NFL picks, an impressive 69% success rate, making him a consistently profitable source for bettors. Anyone who followed Cohen’s NFL predictions found themselves in the green at their preferred sports betting sites and apps.
You can unlock Cohen’s exclusive Week 1 NFL exact score predictions only at SportsLine. Additionally, savvy bettors can leverage the DraftKings promo code, which offers a generous $300 in bonus bets instantly, plus over $200 off NFL Sunday Ticket.
Top Week 1 NFL Picks: Bills vs. Ravens Showdown
After a deep dive into all 16 games, Cohen highlights the Bills (-1.5, 51.5) to secure a narrow victory in a highly anticipated rematch of their AFC Divisional Playoff Game against the Ravens. His predicted final score is 26-23 in favor of Buffalo.
“In my opinion, these are the two best teams in the NFL, and we’ll see this matchup again on Sunday, January 25th, 2026, in the AFC Championship Game,” Cohen states. “I have Buffalo going 15-2 this season but Baltimore winning the Super Bowl. If I had to do a home-field advantage ranking, the passionate Bills crowd would easily be in the top-5, if not No. 1 overall. That’s the difference in a game that should be very similar to last year’s playoff contest narrowly won by Buffalo.”
Based on this compelling score prediction, Cohen recommends backing the Bills on the money line (-119), expecting them to cover the spread, and anticipating the Over to hit in this thrilling matchup. For all of Cohen’s other Week 1 football score predictions, visit SportsLine.
Unlocking High-Scoring Thrillers
Beyond individual game outcomes, Cohen is also projecting one game this week to exceed a staggering 60 total points, making the Over a “must-bet” in that particular contest. Nailing this high-scoring prediction is crucial for making profitable Week 1 NFL picks. This exclusive insight is available only at SportsLine.
Curious to know who wins every Week 1 NFL game, and which matchups are “must-bet” for the Over? Visit SportsLine now to access Eric Cohen’s comprehensive NFL Week 1 score predictions, all from the expert who accurately called nearly 70% of his NFL straight-up picks last season. Don’t miss out on these critical insights!
