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The wait is finally over! The 2025 NFL season kicks off with an electrifying Week 1 schedule, promising gridiron drama and high-stakes action. From Thursday’s highly anticipated NFC East clash to Sunday Night Football’s AFC heavyweight battle and Monday’s division rivalry, fans and bettors alike are gearing up for a captivating start.
While spreads, totals, and money lines dominate most discussions, the allure of an exact score prediction offers a unique thrill and the potential for a massive payday. This year, SportsLine expert and host Eric Cohen, who boasted an impressive 190-95 (69%) record on straight-up NFL picks last season, has meticulously analyzed every matchup to provide his precise score predictions.
Key Week 1 Matchups and Odds
The opening slate features several marquee games:
- Thursday Night Football: Dallas Cowboys vs. Philadelphia Eagles (Eagles -8.5)
- Friday in Brazil: Kansas City Chiefs vs. Los Angeles Chargers
- Sunday Night Football: Buffalo Bills vs. Baltimore Ravens (Bills -1.5, Total 50.5)
- Monday Night Football: Minnesota Vikings vs. Chicago Bears (Vikings -1.5)
- Other notable games include the Pittsburgh Steelers (-2.5) against the New York Jets.
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Cohen’s Marquee Pick: Bills vs. Ravens Rematch
Among his comprehensive Week 1 NFL picks, Eric Cohen is particularly focused on the Sunday Night Football showdown between the Buffalo Bills and the Baltimore Ravens. This game is a rematch of last season’s AFC Divisional Playoff, which the Bills narrowly won. Cohen predicts another tight contest, with the Bills emerging victorious with a final score of 26-23.
“In my opinion, these are the two best teams in the NFL and we’ll see this matchup again on Sunday, January 25th, 2026, in the AFC Championship Game,” Cohen states. He adds, “I have Buffalo going 15-2 this season but Baltimore winning the Super Bowl. If I had to do a home-field advantage ranking, the passionate Bills crowd would easily be in the top-5, if not No. 1 overall. That’s the difference in a game that should be very similar to last year’s playoff contest narrowly won by Buffalo.”
Based on this prediction, Cohen likes the Bills on the money line (-106), to cover the small -1.5 spread, and for the Over (50.5) to hit, despite it being the highest total on the Week 1 NFL odds board.
High-Scoring Affairs: A Must-Bet Over?
Beyond individual game outcomes, Cohen has identified one particular game that he believes will exceed 60 total points, making the Over a “must-bet.” Nailing such a high-total prediction could be incredibly profitable for bettors. To discover which game this is, and to see all of Cohen’s other Week 1 NFL score predictions, you’ll need to visit SportsLine.
Where to Find All Exact Score Predictions
For those eager to dive deep into every Week 1 NFL matchup, Eric Cohen’s complete set of exact score predictions, along with his detailed logic for each game, is exclusively available at SportsLine. Given his proven track record of nearly 70% accuracy on straight-up picks last season, Cohen’s insights are an invaluable resource for anyone looking to make informed NFL picks this week.
Don’t miss out on the opportunity to see which team wins every Week 1 NFL game and which matchups are “must-bet” Overs. Visit SportsLine now to unlock Eric Cohen’s NFL Week 1 score predictions and elevate your betting strategy for the start of the 2025 NFL season.
