
As the 2025 NFL season kicks off, millions of fans are meticulously crafting their survivor pool strategies, hoping to outlast the competition. Week 1 always presents a unique set of challenges and opportunities, and this year is no exception. With high-profile matchups and intriguing storylines, identifying the safest picks while avoiding early pitfalls is paramount.
One team drawing significant attention for Week 1 NFL survivor pools is the Philadelphia Eagles (-8.5, 47.5). Their opening clash against the Dallas Cowboys, especially after the surprising trade of Micah Parsons from Dallas, makes them an immediate favorite for many. However, with a healthy Dak Prescott leading the Cowboys and their historical rivalry with Philadelphia, is deploying the Eagles so early in the season a wise move, or should savvy players save them for a more opportune moment?

The Case Against Arizona in Week 1
While the Philadelphia-Dallas game dominates headlines, other Week 1 matchups warrant careful consideration for survivor pools. The Arizona Cardinals, despite coming off an 8-9 season and entering their game against the New Orleans Saints as 6.5-point favorites, are a team the SportsLine Projection Model is strongly advising against.

Picking against the Saints might seem like a popular Week 1 play, but the Cardinals’ road performance in 2024 raises significant red flags. They finished with a paltry 2-6 record away from home and dropped five of their final seven games last season. New Orleans, despite a disappointing 5-12 overall record in 2024, managed to secure three victories on their home turf, indicating a stronger performance in front of their faithful.

Historical Context and Model Projections
Adding to the Cardinals’ precarious position is their historical record against the Saints. New Orleans, with Spencer Rattler now named the starting quarterback, has won five of the last eight head-to-head matchups dating back to 2007. Furthermore, Arizona has only covered the spread in three of those games, suggesting these contests are typically hard-fought and close.

The SportsLine model, which simulates every NFL game 10,000 times and has an impressive track record of over $7,000 in winnings for $100 players on top-rated NFL picks since its inception (including a stellar 31-15 record on top-rated picks in 2024), projects only a field goal difference between the Cardinals and Saints. It gives Arizona a mere 58% chance of winning, making them an extremely risky Week 1 NFL survivor pick.

Other Week 1 Considerations
Beyond the Cardinals-Saints matchup, other games to ponder for Week 1 survivor pools include the Broncos against the Titans (-7.5) and the Buccaneers (-2.5) versus Atlanta. Each game presents its own set of variables and potential pitfalls, demanding careful analysis before committing to a pick.
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Conclusion
Week 1 of the 2025 NFL season is a minefield for survivor pool players. While popular picks like the Eagles might seem tempting, the data suggests caution. The Arizona Cardinals, despite being favorites, pose a significant risk due to their road struggles and historical performance against the Saints. Trusting advanced models and expert analysis can provide the crucial advantage needed to navigate these early challenges and set the stage for a successful survivor pool run.