
As the 2025 NFL season kicks off, millions of fans and strategists are eyeing their Week 1 NFL survivor pool picks. The opening slate presents a unique set of challenges and opportunities, with several matchups drawing significant attention. From the highly anticipated Eagles-Cowboys clash to intriguing inter-conference battles, making the right choice early can set the tone for your entire season. But with so many variables, which teams offer the safest path to Week 2, and which are best avoided?

The Eagles-Cowboys Conundrum: A Risky Proposition?
The Philadelphia Eagles, currently favored by 8.5 points with an over/under of 47.5, are a popular early pick, especially with the news of Micah Parsons’ trade from Dallas. Their Week 1 matchup against the Cowboys seems appealing on paper. However, history and the presence of a healthy Dak Prescott make this a less straightforward choice than some might assume. While the Eagles are strong contenders, using a premier team like them in Week 1 against a divisional rival, even a potentially weakened one, could be a strategic misstep. Savvy survivor pool players often prefer to save their top-tier teams for later in the season when more predictable matchups emerge.

Other Week 1 Considerations and the Allure of the Underdog
Beyond the NFC East rivalry, other games are drawing attention for Week 1 survivor pools. The Arizona Cardinals, despite coming off an 8-9 season, find themselves as 6.5-point favorites against the New Orleans Saints. Similarly, the Denver Broncos are 8.5-point favorites over the Tennessee Titans, and the Tampa Bay Buccaneers are favored by 2.5 points against Atlanta. Each of these matchups presents its own set of risks and rewards.
The SportsLine Model’s Verdict: Steer Clear of the Cardinals
When it comes to making informed decisions, advanced analytics can be an invaluable tool. The SportsLine Projection Model, which simulates every NFL game 10,000 times and boasts an impressive track record of being up well over $7,000 for $100 players on top-rated NFL picks since its inception (including a remarkable 31-15 record on top-rated picks in 2024), has weighed in on Week 1. Its definitive advice for survivor pool players: stay away from the Arizona Cardinals.

Why the Cardinals Are a Risky Pick
- Road Struggles: Despite their 8-9 record last season, the Cardinals were a mere 2-6 away from home in 2024 and lost five of their last seven games overall. This doesn’t inspire confidence for a road game to open the season.
- Saints’ Home Advantage: While the New Orleans Saints finished 5-12 last year, they managed to secure three wins on their home turf. With Spencer Rattler now named the starting quarterback, a renewed energy could be present.
- Historical Head-to-Head: New Orleans has won five of the last eight matchups against Arizona dating back to 2007. Furthermore, the Cardinals have only covered the spread in three of those games, indicating consistently competitive contests.
- Tight Projections: The SportsLine model projects only a field goal difference between the two teams. Even as -288 money-line favorites, the model gives the Cardinals just a 58% chance of winning outright, making them a high-risk proposition for a survivor pool where a single loss means elimination.

The Model’s Confident Choice: A Surprising Winner
Instead of the Cardinals, the SportsLine model has identified a “surprising team” that it confidently backs to win outright in nearly 80% of its simulations. This team represents a strong, yet perhaps overlooked, opportunity for Week 1 success in your survivor pool. The model emphasizes that “the time to pick this team is now.”

Final Thoughts for Week 1
Week 1 of the 2025 NFL season is a minefield of potential upsets and strategic dilemmas. While popular picks like the Eagles might seem appealing, the deeper analysis suggests caution. For those aiming to navigate the survivor pool with precision, heeding the advice to avoid the Arizona Cardinals and instead trusting the SportsLine model’s top pick could be the key to advancing. Remember, in survivor pools, survival is paramount, and sometimes, the safest path isn’t the most obvious one.
To see which surprising team the SportsLine model is backing for Week 1, and to gain access to all its advanced analytics and picks, visit SportsLine today. Additionally, new users can take advantage of the DraftKings promo code offering $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket, or the latest FanDuel promo code for $300 in bonus bets instantly.