Sophia
The anticipation for the 2025 NFL season is reaching a fever pitch, with Week 1 kicking off in just one day. As fans and bettors alike pore over the Week 1 NFL odds, a clear trend emerges: nearly a dozen games feature a spread of a field goal or less, indicating a slate of tightly contested matchups. From the Chiefs vs. Chargers (+3) to the Buccaneers vs. Falcons (+2.5), every point will matter.
Only two contests boast Week 1 NFL spreads exceeding a touchdown. Cam Ward’s professional debut sees his Titans as 7.5-point underdogs against the Broncos, while the Cowboys face an even steeper climb, trailing the Eagles by 8.5 points. Regardless of your preferred NFL betting trends, starting the 2025 NFL season with winning football bets is paramount.
For those seeking an edge, SportsLine’s advanced computer model, with a proven track record of success, offers comprehensive NFL betting advice and predictions for every Week 1 matchup. This model, which simulates every NFL game 10,000 times, has generated over $7,000 for $100 players on top-rated NFL picks since its inception, including an impressive 31-15 record on top-rated picks in 2024. Following its insights has consistently yielded strong returns for bettors.
New users can also take advantage of exciting promotions, such as the DraftKings promo code offering $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket, or bet NFL Week 1 at bet365 to receive $200 in bonus bets instantly.
Let’s dive into some of the model’s strongest Week 1 NFL predictions:
Bengals to Dominate Browns on the Road
One of the model’s most confident Week 1 NFL picks favors the Cincinnati Bengals (-5.5, 47.5) to cover the spread on the road against the Cleveland Browns. While the Browns’ starting quarterback remains uncertain, the Bengals boast one of the league’s most prolific passers in Joe Burrow.
Last season, Burrow led the NFL in both passing yards (4,918) and passing touchdowns (43), becoming only the third player in NFL history to achieve at least 4,500 yards, 40 touchdowns, and fewer than 10 interceptions in a single season. With Ja’Marr Chase and Tee Higgins both signing extensions this offseason, the league’s top-ranked passing offense from a year ago returns fully intact.
Cincinnati’s aerial attack alone could outscore a Cleveland offense that ranked dead-last in scoring in 2024. The Browns struggled across the board, finishing last in third-down offense, committing the second-most turnovers, and ranking in the bottom five for both rushing offense and redzone scoring. Furthermore, Cleveland’s defense, which led the NFL in yards allowed in 2023, slipped considerably, finishing 27th in points allowed in 2024.
The model projects a double-digit victory for Cincinnati (-5.5), with the Bengals covering the spread in over 50% of simulations. This pick highlights the stark contrast in offensive firepower and recent team performance between the two AFC North rivals.
Packers Poised for Home Victory Against Lions
Another compelling Week 1 NFL prediction from the model sees the Green Bay Packers (-2.5, 47.5) covering at home against the Detroit Lions. The line has already shifted one point in favor of Green Bay since the blockbuster trade for Micah Parsons, underscoring the immediate impact of his arrival.
The Washington Commanders’ road playoff win last season against Detroit may have provided a blueprint for exploiting the Lions. Jared Goff was frequently pressured in that game, leading to four turnovers. Few teams are as adept at applying pressure and creating takeaways as Green Bay, which ranked fourth in turnovers created last year and finished with more sacks than all but seven teams, despite blitzing at the second-lowest rate in the league.
Detroit also faces significant offseason attrition, having lost both of its coordinators and three-time All-Pro center Frank Ragnow. Conversely, the Packers addressed a key need by drafting Matthew Golden in the first round, providing the team with a much-needed No. 1 wideout. The model projects Golden to make an immediate impact, leading the Packers in receiving in Week 1. Green Bay’s defense is also projected to generate more sacks and takeaways than Detroit’s.
With these factors in play, the Packers (-2.5) are projected to cover nearly 60% of the time, with the Over (47.5) hitting in over 50% of simulations.
How to Maximize Your Week 1 NFL Picks
The SportsLine model has analyzed every game on the Week 1 NFL schedule, identifying not only the winners and spread-coverers but also three underdogs poised for outright victories, offering potentially massive payouts. These exclusive picks, along with comprehensive betting advice for every matchup, are available only at SportsLine.
Don’t miss out on the opportunity to start the 2025 NFL season with confidence. Review the latest NFL odds below, then visit SportsLine to unlock every pick from the proven computer model that has consistently delivered strong returns for its followers.
Week 1 NFL Betting Odds, Lines, Live Spreads, Scores
| Game | Spread | Total | Picks |
|---|---|---|---|
| Cowboys at Eagles (Thursday) | PHI -8.5 | 47.5 | SEE PICKS HERE |
| Chiefs at Chargers (Friday) — in Brazil | KC -3 | 45.5 | SEE PICKS HERE |
| Buccaneers at Falcons | TB -2.5 | 46.5 | SEE PICKS HERE |
| Bengals at Browns | CIN -5.5 | 47.5 | SEE PICKS HERE |
| Dolphins at Colts | IND -1 | 47 | SEE PICKS HERE |
| Panthers at Jaguars | JAX -3.5 | 46.5 | SEE PICKS HERE |
| Raiders at Patriots | NE -2.5 | 42.5 | SEE PICKS HERE |
| Cardinals at Saints | ARI -6.5 | 42.5 | SEE PICKS HERE |
| Steelers at Jets | PIT -2.5 | 38.5 | SEE PICKS HERE |
| Giants at Commanders | WAS -6 | 45.5 | SEE PICKS HERE |
| Titans at Broncos | DEN -7.5 | 41.5 | SEE PICKS HERE |
| 49ers at Seahawks | SF -2.5 | 44.5 | SEE PICKS HERE |
| Lions at Packers | GB -2.5 | 47.5 | SEE PICKS HERE |
| Texans at Rams | LAR -3 | 44 | SEE PICKS HERE |
| Ravens at Bills | BUF -1 | 51.5 | SEE PICKS HERE |
| Vikings at Bears (Monday) | MIN -1.5 | 44.5 | SEE PICKS HERE |
