Sophia
As the 2025 NFL season rapidly approaches, football enthusiasts and bettors alike are gearing up for a Week 1 full of intriguing matchups and tight betting lines. Whether you’re an early bird looking to seize value or a last-minute strategist, the opening week presents a landscape of nearly a dozen games with spreads of a field goal or less, promising an exhilarating start to the season.
From the Jets vs. Steelers (-3) to the 49ers vs. Seahawks (+2.5), and the Packers vs. Lions (+2.5) to the Rams vs. Texans (+2.5), competitive action is the theme. The only game featuring a spread over a touchdown sees rookie quarterback Cam Ward making his professional debut as his Titans are 7.5-point underdogs against the Broncos. To navigate these NFL betting trends, SportsLine’s advanced computer model offers crucial insights and predictions for every Week 1 NFL pick.
SportsLine’s Model: A Proven Track Record
The SportsLine model, which meticulously simulates every NFL game 10,000 times, has an impressive track record. It has generated well over $7,000 for $100 players on top-rated NFL picks since its inception, boasting a remarkable 31-15 record on top-rated picks in 2024. This consistent performance underscores its reliability for those looking to make informed football bets.
For new users, DraftKings Sportsbook is offering a compelling promo code that includes $300 in bonus bets instantly, plus over $200 off NFL Sunday Ticket. Additionally, bet365 provides new users with $200 in bonus bets instantly for Week 1 NFL wagers.
Top Week 1 NFL Predictions: Bengals and Packers Poised for Success
Cincinnati Bengals vs. Cleveland Browns
One of the model’s most confident Week 1 NFL picks is the Cincinnati Bengals (-5.5, 47.5) covering the spread on the road against the Cleveland Browns. The uncertainty surrounding Cleveland’s starting quarterback pales in comparison to the known dominance of Joe Burrow for the Bengals.
Last year, Burrow led the league in both passing yards (4,918) and passing touchdowns (43), joining an elite group of only three players in NFL history to achieve at least 4,500 yards, 40 touchdowns, and fewer than 10 interceptions in a single season. With Ja’Marr Chase and Tee Higgins locked into extensions, the league’s top passing offense from 2024 returns fully intact, ready to light up scoreboards.
Conversely, Cleveland’s offense struggled mightily in 2024, finishing dead-last in scoring. They also ranked last in third-down offense, committed the second-most turnovers, and were in the bottom five for both rushing offense and redzone scoring. The Browns’ defense, which led the NFL in yards allowed in 2023, also regressed significantly, dropping to 27th in points allowed in 2024. The model projects a double-digit victory for Cincinnati, with the Bengals covering over 50% of the time.
Green Bay Packers vs. Detroit Lions
Another strong Week 1 NFL prediction from the model favors the Green Bay Packers (-2.5, 47.5) covering at home against the Detroit Lions. The line has already shifted a point in Green Bay’s favor following the blockbuster acquisition of Micah Parsons, a move that significantly bolsters their defensive prowess.
The Washington Commanders’ playoff victory over Detroit last season provided a potential blueprint for success: relentless pressure on Jared Goff, leading to turnovers. Green Bay excels in this area, ranking fourth in turnovers created and among the top seven in sacks last year, despite blitzing at the second-lowest rate in the league. Parsons’ arrival only enhances this formidable pass rush.
Detroit also faces significant offseason attrition, having lost both of its coordinators and three-time All-Pro center Frank Ragnow. The Packers, conversely, addressed their primary need by drafting Matthew Golden in the first round, providing a much-needed No. 1 wideout. The model projects Golden to make an immediate impact, leading the Packers in receiving in Week 1. With Green Bay’s defense projected to have more sacks and takeaways than Detroit, the Packers (-2.5) are predicted to cover nearly 60% of the time, with the Over (47.5) hitting in over 50% of simulations.
Unlock All Week 1 NFL Picks
The SportsLine model has analyzed every game on the Week 1 NFL schedule, identifying not only the winners and spread-covers but also three underdogs poised for outright victories, offering potentially significant payouts. To get every pick for every game, visit SportsLine.
Don’t miss out on the opportunity to make confident NFL picks. Check out the latest NFL odds below, then head to SportsLine to see which teams will win and cover the spread, all backed by a proven computer model that has consistently delivered strong returns.
Week 1 NFL Betting Odds, Lines, Live Spreads, Scores
Get Week 1 NFL picks at SportsLine
| Game | Spread | Total | Picks |
|---|---|---|---|
| Cowboys at Eagles (Thursday) | PHI -7.5 | 47.5 | SEE PICKS HERE |
| Chiefs at Chargers (Friday) — in Brazil | KC -3 | 45.5 | SEE PICKS HERE |
| Buccaneers at Falcons | TB -2.5 | 46.5 | SEE PICKS HERE |
| Bengals at Browns | CIN -5.5 | 47.5 | SEE PICKS HERE |
| Dolphins at Colts | IND -1.5 | 47 | SEE PICKS HERE |
| Panthers at Jaguars | JAX -3 | 46.5 | SEE PICKS HERE |
| Raiders at Patriots | NE -2.5 | 42.5 | SEE PICKS HERE |
| Cardinals at Saints | ARI -6.5 | 42.5 | SEE PICKS HERE |
| Steelers at Jets | PIT -3 | 38.5 | SEE PICKS HERE |
| Giants at Commanders | WAS -6 | 45.5 | SEE PICKS HERE |
| Titans at Broncos | DEN -7.5 | 41.5 | SEE PICKS HERE |
| 49ers at Seahawks | SF -2.5 | 44.5 | SEE PICKS HERE |
| Lions at Packers | GB -2.5 | 47.5 | SEE PICKS HERE |
| Texans at Rams | LAR -2.5 | 44.5 | SEE PICKS HERE |
| Ravens at Bills | BUF -1 | 51.5 | SEE PICKS HERE |
| Vikings at Bears (Monday) | MIN -1.5 | 43.5 | SEE PICKS HERE |
